The Cytokines-Directed Roles of Spirulina for Radioprotection of Lacrimal Gland.

Atilgan H. I., Akbulut A., Yazihan N., Yumusak N., Singar E., Koca G., ...Daha Fazla

Ocular immunology and inflammation, cilt.31, sa.2, ss.271-276, 2023 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 31 Sayı: 2
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1080/09273948.2022.2026409
  • Dergi Adı: Ocular immunology and inflammation
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.271-276
  • Anahtar Kelimeler: Radioiodine (RAI), spirulina, radiation, radioprotection, cytokines, DOSE RADIOIODINE THERAPY, DIFFERENTIATED THYROID-CARCINOMA, RADIOACTIVE IODINE THERAPY, OXIDATIVE STRESS, SALIVARY, DYSFUNCTION, SUPPLEMENTATION, OBSTRUCTION, PROTECTION, ABLATION
  • Ankara Üniversitesi Adresli: Evet

Özet

Purpose To evaluate the radioprotective effect of spirulina (SP) on the lacrimal glands after RAI treatment. Methods A total of 30 rats were separated into control, RAI and SP group. The radioprotective effect of SP on lacrimal glands was evaluated with histopathological and cytopathological analysis. Lacrimal glands were analyzed for tumor necrosis factor alpha (TNF-alpha), interleukin-2 (IL-2), IL-4, IL-6, IL-10, nuclear factor-kappa B (NF-kappa B), total oxidant status (TOS) and total antioxidant capacity (TAC) levels. Results RAI increased TNF-alpha (p = .001), IL-6 (p = .018), and NF-kappa B levels (p < .0005). Following the administration of SP, TNF-alpha (p < .0005), IL-4 (p = .026), and IL-6 (p = .006) levels decreased. RAI decreased the TAC levels (p = .001), and co-administration of SP increased the TAC level, but was not statistically significant. SP decreased the TOS level after RAI (p = .022) . Conclusions SP protects lacrimal glands from RAI-induced damage.